Systematic engineering

Introduction

(Systems Bio-Engineering, Biosystem Engineering)

System Biological Engineering is a systematic engineering application, including systematic biology Medical, agriculture, industrial, environment, ocean and space biotechnology and its engineering application development. In 1991, China Zeng Bangzhe (Zengjie) issued a "scientific structure and China's future" monteph of solar-biological-electronic technology, as well as the development of system science, artificial intelligence and genetic engineering, issued in 1994 " Biological Engineering Category, proposed the integrated concept of genomic blueprint design and biological machine assembly, biomolecular computers and cell bionic engineering and other bionics and genetic engineering, in 1999 Zeng Bangzhe expressed manually developed genomic procedures and design cells in 1999 The "Artificial Biosystem" conceptual diagram of the molecular circuit system, in which the design and assembly of cytokinetical molecular machines for computer learning and bionics and transgenic engineering are carried out from "Artificial Life".

System Biology Practice Bi Talain's Biological System Open Theory or Physics and Biology General System Theory and Theoretical Biology, System Science is initially systematic engineering, is a group of physics, Systematic theory, systemism, informationism, controlism, synergistic, dissipative structural theory, compliance theory, synergistic, dissipative structure, super-cycle theory, etc. in the field of chemical, biology, and super cycle theory, and systemic tidalism and physics biology. Formation, the earliest discipline vocabulary is systematic psychology (Systems Psychology, Parry JB 1958), and then systematic ecology, systematic physiology and system genetics constitutes biology (Systems Biology vocabulary 1993 in Zieglgansberger W and Tolle Trism) The three major branch disciplines and other three major branch disciplines were applied to medical and biological engineering.

System Biology

System Biology (Systems Biotechnology), can be briefly described as a bionic engineering, genetic engineering and biological system theory of integration discipline, involving system science, information science High intersection and synthesis of computer science, nanoscience, biological science, medical science and engineering science. From the nervous system of animal and communication behavior, the intelligent robot engineering technology of brain science is developed to cell signaling, gene expression regulates synthetic biotechnology development of manual design, forming two basic directions of transforming organisms and patterns, and will be in solar energy Biological engineering, secondary metabolic project, the development of cell pharmaceutical factories and biocompatient development creates future biomaterials, bioenergy and biological information industries. System science is applied to bioengineering, such as systematic science and computer, automation, and communication technology, theoretical research to application development, also leads to transformation between system biotechnology to conversion (transforming science or transformation of biology) The distance is shortened.

Development

The success of the 20th century, the success of molecular biology and genomic plan, the beginning of the 21st century, international system biology and medicine, bioengineering applications in cell signaling and gene Expressing the level of control and rapidly become the development of global modern technology development. In 2008, China established the Biological Engineering Research Institute, subsequently, international and domestic system biological projects, and the rapid establishment and development of molecular system biocontrol research institutions. Calculate the development of biology, nanobiology, chemistry, synthetic biology, mathematical model and artificial biological system computer aided design, gene and even genomic synthesis, large-scale high-throughput chip especially microfluidic chip, and physical biology In combination with nano-biotechnology, new prospects have brought new prospects for systematic biological engineering in cells, molecular hierarchy.

Biotechnology Development to Biotechnology and Bioengineering, System Bioengineering Establishment in Biological Systems and Chemical Engineering, Electronic Engineering, Computer Engineering and Biotechnology, Biomedical, etc. Based on the high intersection, Biomedical Engineering, Biosystems Engineering is integrated in the systematic bioengineering hierarchy.

Year of the year

System science, bioinformatics and biomedicine, biological technology, etc., forming biological system, forming modern system biology, system medicine concept; entity or Biological engineering of organisms and biological systems of virtual or computers - Artificial Biosystems - forming modern synthetic biology, systematic biological engineering concept.

1) China Zeng Bangzhe (Zeng Jie), China Solar biological electronics technology, such as genetic engineering, etc .:

· 1992 proposes gene and neural two-way regulatory model to 1997 cell signaling and gene regulation network;

· 1993 Annual published system scientific structure - generalized theory, system structure, steady state, and dynamics, etc .;

· 1994 issued cell bionic engineering and artificial design organism system biological engineering, complex system genes Role system genetics and genetic systems, protein systems, interrelationships of the enzyme system and corresponding structural or the like and transgenic system methods and tubal bioreactors, and the like.

2) China Zengbangzhe (member of the Secretary-General) in Beijing's first international transgenic animal academic seminar, communication with Avigenics, etc., in the conference and international communications, the system bioengineering, fallopian tube biological response Wait:

· 1997-1998 using CHO cell chemical mutagenesis screening to high anti-pharmacy, continuous mutation is a point of view of nonlinear genetics;

· 1999 advocates molecular organisms Research and Development of Biological Systems and Artificial Biological Systems (Genetic Machinery, Cellular Electronics or Computers Integrated Genetic Machines, Cellular Electronics or Computers, etc.);

· 2001 Japan North Ye Ming The system biological core view of the derity is the structure, steady state and kinetic model, biotechnology and biological calculation method integrated biological system research;

· 2002 nonlinear cell dynamics, and Cell computer molecular system module and artifacts;

· 2002 Norwegian established 2003 first integrated genetics laboratory with Zengbangzi in Germany to discuss genetic concept communication;

· 2008 Steven Benner in Nature Posted System Biology and Synthetic Biology of Synthesis Biology.

3) 2003-2010 China Zeng Bangzhe (Zengjie) in the International Genetics Conference, International Biotechnology Conference, World Philosophy, International Conference on Biology and System Biology, International Meetings, China Technical conferences and exhibitions, domestic and foreign publications and publications.