Chen Zhijian (Academician of the National Academy of Sciences, Immunologist)

Character experience

Chen Zhijian (8 photos)

In 1979, when he was 13 years old, he entered the No. 1 Middle School in Anxi County, Fujian Province.

In 1981, he graduated from the No. 1 Middle School in Anxi County, Fujian Province and was admitted to Fujian Normal University.

In 1985, after graduating from the Biology Department of Fujian Normal University, he was admitted to Fujian Normal University for a master's degree in biochemistry. His foreign language score ranked first in the province and he was under the tutelage of Professor Yu Baosheng.

In 1986, he was admitted to the State University of New York to pursue a Ph.D.

In 1991, he obtained a Ph.D. in biochemistry from the State University of New York, and then went to the Sauk Institute in San Diego to do postdoctoral research.

In 1997, he joined the University of Texas Southwestern Medical Center and served as an assistant professor, associate professor, and tenured professor in the Department of Molecular Biology.

In 2005, he served as a researcher at the Howard Hughes Medical Institute in the United States.

In 2014, he was elected as a member of the National Academy of Sciences.

Main Achievements

Research Achievements

• Research Summary

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Chen Zhijian’s main achievements include the discovery of the function of ubiquitin as a signal molecule, and the role of mitochondrial antiviral signal protein, the sensor molecule of virus infection, in the process of RNA virus infecting the host. In particular, from February to August 2013, four consecutive academic papers were published in the American "Science" journal, on how the body’s immune cells initially recognize pathogenic microorganisms or heterologous DNA in the body, which has long plagued the biomedical community for many years. The problem was systematically elucidated, and the endogenous second messenger cGAMP molecule and its synthetase that played a key role in it were discovered, which opened up a new research direction in the field of immunobiology, and provided a basis for the diagnosis of lupus erythematosus and AIDS, and the research and development of vaccines. New ideas also provide new ways for future clinical drug development to prevent and treat infectious diseases, cancer, and autoimmune diseases.

• Academic treatises

As of March 2015, Chen Zhijian has been the corresponding author in the world Top journals "Cell" (7 articles), "Nature" (2 articles), "Science" (4 articles), "Immunity" (2 articles) and "Molecular Cell" He has published a series of scientific research papers on Molecular Cell (8 articles), and his articles have been cited more than 23,000 times by scientists from various countries.

Talent training

• Educational thought

Chen Zhijian emphasizes on scientific research Interest is very important. Only if there is interest, there will be motivation and perseverance. It also emphasizes the importance of the scientific research team.

Honorary Recognition

Time	Honorary recognition	Awarding unit
1998	Searle Scholar Award
2005	Norman Hackerman Award in Chemical Research	< /td>
2007	< p>The Edith and Peter O'Donnell Award in Science	Texas Medicine, The Academy of Medicine, Engineering and Science of Texas
2012	NAS Award in Molecular Biology	National Academy of Sciences
May 2014	Outstanding Alumni Meritorious Medal	Fujian Normal University
2015	ASBMB-Merck Award	American Society for Biochemistry and Molecular Biology p>
2018	The Lurie Prize in Biomedical Sciences	National Institutes of Health Foundation< /p>
October 2018	Life Science Breakthrough Prize in Life Sciences
< p>2020	William B. Coley Award

Social Service

Time	Accepting position
2012	Guest Professor of Fujian Normal University
January 2017	< p>Honorary Professor of Peking Union Medical College
	National Institutes of Health Biochemistry and Molecular Genetics Member of the Program Review Committee
	< p>Member of the American Heart Association Review Committee
	Co-chair of the genetic and developmental graduate program at the University of Texas Southwestern Medical Center, member of the Steering Committee of the Graduate School, member of the Graduate Advisory Committee, member of the Postdoctoral Advisory Committee, member of the Medical Scientist Training Program td>

Personal life

When Chen Zhijian was young, his father worked in Nanping and his mother worked as a private teacher in Nandou Primary School. He is the eldest son of the family, and while studying, he also helps his mother take care of his two younger brothers.

Character evaluation

Chen Zhijian is concerned about the motherland and strives to promote the development of Chinese medical science and technology innovation. (Chinese Academy of Medical Sciences & Peking Union Medical College Review)

Chen Zhijian is one of the representatives of the highest intellectual level of the Chinese, and his achievements mark the pinnacle that Chinese biologists aspire to reach . (Academician of the National Academy of Sciences, Director of Peking University Biomedical Frontier Innovation CenterXie XiaoliangComment)

Chen Zhijian is in the field of natural immunity One of the pioneers of CGA, and the discoverer of important natural immune molecules such as cGAS, cGAMP, and MAVS. (Peking University Review)

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